Longevity, Anti-Aging & Hyperbaric ChambersHyperbaric Therapy may have significant anti-aging effects |
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Background:At the cellular level, there are two key hallmarks of the aging process: shortening of telomere length and cellular senescence. Telomeres are located at the end of the chromosomes which maintain genomic stability. Telomere length (TL), gradually shortens per year. When TL reaches a critical length, cells cannot replicate and progress to senescence (arrest of the cell cycle) or programmed cell death (apoptosis). Accumulation of senescent cells contributes to aging. Lifestyle interventions including endurance training, diets and supplements have reported small effects 2-5% effects on TL. Telomeres are highly sensitive to oxidative DNA damage, which can induce telomere shortening and dysfunction which implicates the use of anti-oxidants for preventing telomere damage. Telomere elongation followed by telomere length reduction, in leukocytes from divers exposed to intense oxidative stress—implications for tissue and organismal aging. Part of the mechanism involved in TL is the "hyperoxic hypoxic paradox": intermittent hyperoxic (high oxygen) exposures induce an adaptive response which includes increased upregulation of antioxidants genes and antioxidants / scavengers that adjust to the increased ROS generation. However, because the scavenger elimination half-life (T1/2) is significantly longer than the T1/2 of ROS, upon return to normoxia, with repeated hyperoxic exposures, there are significantly higher levels of scavengers and increased antioxidant activity.
Cognitive aging is part of the normal aging process. Processing speed, conceptual reasoning, memory and problem-solving activities are the main domains which decline gradually over time. Decreases in cerebral blood flow is strongly associated with reductions in cognition with age. Enhancing NAD+ levels, as we do at our office in Edmonton with NAD+ IV Therapy, has been shown to elongate telomeres in humans and mice - and, as such, is highly synergistic with Hyperbaric Oxygen. Hyperbaric Effects in LongevityNumerous mechanisms are related to the effects of Hyperbaric Oxygen Chambers in longevity:
Telomere LengtheningPreliminary data regarding Hyperbaric Oxygen Chambers and Telomere length was reported in 2011 by Shlush. Telomere length parameters over 12-months, in divers exposed to Hyperbaric Oxygen were compared to age-matched controls and significant telomere elongation was observed in granulocytes and naïve T cells.
More recently, a study by Hachmo 2020 looked at Telomere Length (TL) and senescence in immune cells. Out of 35 initial subjects over the age of 64 (average age of about 68), 20 of which underwent senescent cell analysis and 26 underwent telomere length analysis. Protocol included 60, 90 minute sessions of 100% oxygen at 2 ATA (including three five minute air breaks to minimize the risk of oxygen toxicity) and to utilize the hyperoxic hypoxic paradox. Telomere length of T helper, T cytotoxic, natural killer and B cells increased significantly by over 20% following Hyperbaric Oxygen Chamber Treatment. The most significant change was noticed in B cells which maximally increased by 37.63%. Senescent T helpers decreased by up to 37% and T-cytotoxic senescent cell percentages decreased significantly by about 11% after Hyperbaric Oxygen Treatment. TL and senescent cell reduction peaked at the 30th session which possibly suggests that we can achieve results without going to 60 sessions which is fairly treatment intensive. At our Edmonton office, our Naturopathic Doctors also use IV NAD+ in conjunction with Hyperbaric Chamber Therapy, which in-part, offsets telomere DNA damage. Cognitive EnhancementHadanny 2020 looked at using Hyperbaric Chambers for cognitive enhancement in older adults. 63 healthy adults were randomized to either to HBOT (n=33) or control arms (n=30) for three months. HBOT arm patients were slightly older (70.7 compared to 68.8 years of age). 60, 90 minute HBOT sessions at 2.0 ATA (with a five minute air break) were used. Primary endpoints included the general cognitive function measured post intervention. Cerebral blood flow (CBF) was evaluated by perfusion MRI. Significant improvement in global cognitive function was seen post-HBOT and the most striking improvements were seen in attention and information processing speed, with enhancements in executive functions seen as well. Both overall memory score, the immediate and the delayed nonverbal memory scores were also improved post-HBOT as well as verbal memory and fluency albeit these improvements were not statistically significant. Significant cerebral blood flow increases were seen in the HBOT group compared to the control group in numerous brain areas (but an insignificant increase in whole brain CBF and whole grey matter CBF). Correlations were seen between cognitive score changes and these regional perfusion changes. There was a significant increase in the HBOT group’s energy levels. This study speaks to the idea that not only can HBO be potentially used to preserve cognitive function, but to enhance it in the absence of other interventions. At our Edmonton office, Hyperbaric Chambers are certainly used to enhance cognition, usually over an 8 week period, which pairs well with IV NAD+ which can enhance cognition almost immediately in some patients. Physical EnhancementHadanny 2024 looked at using Hyperbaric Chambers for physical enhancement in older adults. The same 63 healthy adults as the above mentioned study from 2020 were examined. As above, HBOT (n=33) or control arms (n=30) for three months. 60, 90 minute HBOT sessions at 2.0 ATA (with a five minute air break) were used. Primary endpoints included the maximal oxygen consumption (VO2Max) on a cycle ergometer. Secondary endpoints included cardiac perfusion, evaluated by magnetic resonance imaging and pulmonary function. Significant improvement in VO2 was observed post-HBOT and both cardiac blood flow and cardiac blood volume exhibited significant increases when compared to the control group. The authors concluded "the findings of the study indicate that HBOT has the potential to improve physical performance in aging adults." At our office, IV Therapy is primarily used to enhance physical capacity in older adults - we have seen this effect in both the IV Myers as well as NAD+ in our Edmonton patients.  Hyperbaric Chambers and LongevityNaturopathic Medicine & LongevityFasting is one well known approach with regards to life prolongation: Restricting food intake to 40% of usual energy intake increased the mean life span of rats by 33% possibly through increased levels of NAD+. Dr. Dale Bredesen has published some excellent literature on Functional and Naturopathic medicine approaches to cognitive enhancement termed "ReCODE" – reversal of cognitive decline – a protocol that has reversed symptoms in patients with mild cognitive impairment and Alzheimer’s disease. Easy assessments such as a1c, crp, fasting blood glucose and insulin and homocysteine and serum zinc are basics of the protocol which are simple labs we run at our Naturopath clinic in Edmonton. Looking at chronic infections, intermittent fasting, ketosis and heavy metal load are also easy part of Dr. Bredesen's approach that our Naturopaths frequently run at our Edmonton office. Dietary supplementation with a mix of S-adenosyl-methionine (SAMe) and a polysaccharide extract of Astragalus has been shown to increase telomere length of circulating lymphocytes of healthy older adult volunteers. Sirtuins interact with all the major conserved longevity pathways, for example AMPK and insulin–IGF1 signalling, protein kinase A (PKA), mTOR, fork head box O (FOXO) and IGF1. SIRT1 utilizes NAD+ as a co-substrate to promote the deacetylation of specific protein substrates. Resveratrol appears to be a SIRTUIN activating factor. Many studies have shown that Resveratrol can extend maximal lifespan in yeast, worms, flies, fish and even honeybees. Metformin, which activates AMPK also increases NAD+ levels.
Our Naturopathic Doctors are well experienced with the administration of IV NAD+ and oral Resveratrol and can mirror the effects of Metformin with Berberine. Furthermore, in the context of longevity, we consider the use of oral and IV Glutathione as a means of reducing oxidative stress. Ultimately, at our Edmonton office, we are able to combine Hyperbaric Oxygen, IV NAD+, IV Glutathione, as well as dietary and supplementary interventions on a foundation of Functional Medicine testing for robust longevity promoting effects. Questions?Get in touch
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IV Therapies for Longevity in EdmontonAt TruMed Naturopathic Medicine, we offer advanced intravenous (IV) nutrient therapies designed to support healthy aging, cellular repair, and metabolic resilience. Longevity medicine focuses on maintaining optimal cellular function, reducing oxidative stress, and supporting energy metabolism as we age. IV nutrient therapy allows vitamins, minerals, and antioxidants to bypass the digestive system, delivering therapeutic concentrations directly into the bloodstream. This approach can support mitochondrial function, detoxification, immune health, and metabolic balance—core biological systems linked to healthy aging. Our longevity IV therapies in Edmonton include NAD+, Myers Cocktail, Glutathione, and Iron Infusions, each targeting different aspects of cellular health and age-related decline. NAD+ IV Therapy for LongevityNAD+ (Nicotinamide Adenine Dinucleotide) is one of the most important molecules involved in cellular energy production and longevity biology. NAD+ levels naturally decline with age, which may contribute to fatigue, metabolic dysfunction, and impaired cellular repair. NAD+ plays a central role in:
Low NAD+ levels have been associated with many age-related conditions including metabolic syndrome, neurodegeneration, and chronic fatigue. NAD IV therapy in Edmonton provides NAD+ directly into the bloodstream, supporting cellular energy systems and potentially improving mitochondrial function. Many patients pursue NAD therapy as part of a comprehensive longevity strategy to support:
At TruMed Naturopathic Medicine, NAD+ IV protocols are carefully administered by trained medical professionals and individualized based on patient goals and tolerance. Myers Cocktail IV Therapy for Longevity and Nutrient OptimizationThe Myers Cocktail is one of the most well-known and widely used IV nutrient therapies in integrative medicine. Originally developed by physician John Myers, this IV formula combines essential vitamins and minerals that support cellular metabolism and systemic health. A typical Myers Cocktail contains:
These nutrients play important roles in mitochondrial energy production, nerve function, cardiovascular health, and antioxidant protection. For longevity, Myers Cocktail IV therapy may support:
Because many patients have suboptimal levels of magnesium and B vitamins due to stress, medications, or digestive conditions, IV therapy provides rapid restoration of critical metabolic cofactors. Patients seeking Myers Cocktail IV therapy in Edmonton often use it as part of an ongoing wellness and longevity program. Glutathione IV Therapy: The Master AntioxidantGlutathione is often called the body’s “master antioxidant.” It plays a critical role in detoxification, mitochondrial protection, and defense against oxidative damage—one of the key drivers of biological aging. Glutathione supports longevity through several mechanisms:
Glutathione levels tend to decline with age, chronic illness, environmental toxin exposure, and stress. Glutathione IV therapy in Edmonton allows high concentrations of this antioxidant to reach tissues quickly and effectively. Many patients report improvements in energy, recovery, and overall well-being when glutathione levels are optimized. At TruMed Naturopathic Medicine, glutathione is frequently combined with other IV therapies as part of a comprehensive longevity protocol. Iron Infusions and LongevityIron is an essential mineral required for oxygen transport, mitochondrial function, and energy production. Even mild iron deficiency can lead to fatigue, impaired cognition, reduced exercise capacity, and decreased cellular energy. Iron is necessary for:
Iron deficiency is surprisingly common, especially among women, athletes, and individuals with digestive conditions that impair absorption. For patients who cannot tolerate oral iron or who require rapid repletion, iron infusions in Edmonton can restore iron levels safely and efficiently under medical supervision. Correcting iron deficiency may contribute to improved energy, cognitive function, and overall metabolic health, which are key components of healthy aging. At TruMed Naturopathic Medicine, iron infusions are only recommended after appropriate laboratory testing confirms deficiency, ensuring safe and targeted treatment. Personalized Longevity IV Therapy in EdmontonLongevity medicine is not a one-size-fits-all approach. At TruMed Naturopathic Medicine, IV therapies are integrated into personalized treatment plans that may include:
Our goal is to help patients maintain optimal energy, resilience, and long-term health through evidence-informed integrative medicine. If you are looking for NAD IV therapy, Myers Cocktail IV therapy, glutathione infusions, or iron infusions in Edmonton, our medical team can help determine which therapies best support your longevity goals |